Manfred Schuster,Gottfried Himmler,Guenter Waxenecker,Geert C. Mudde,Manuela Loidl,Gerda Redl,Hans Loibner
申请号：
US12786378
公开号：
US08323650B2
申请日:
2010.05.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
