Antibodies specific for human integrin alpha 5 - beta 1 and their uses for treating tumours

• 收藏
• 分享

专利权人:

PFIZER INC.

发明人:

BENDER, STEVEN, LEE,CASPERSON, GERALD, FRIES,HU-LOWE, DANA, DAN,JIANG, XIN,LI, GANG,NORTH, MICHAEL, AIDAN,WANG, JIANYING,WICKMAN, GRANT,BRAMS, PETER,HUANG, HAICHUN,DEVAUX, BRIGITTE,CHEN, HAIBIN,TANAMA

申请号：

NZ58744009

公开号：

NZ587440A

申请日:

2009.02.04

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

587440 Provided is an antibody binding integrin alpha 5 beta 1, comprising specified sequences of the six CDRs. Further provided are antibody variants with mutated Fc region, with increased ADCC activity compared to the un-mutated antibody. The antibody can be used to inhibit growth of tumour cells expressing integrin alpha 5 beta 1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/