POWELL JOHN,MAGINN MARK,CASSON DUNCAN,BEST ANDREA,HALL JERRY A.,LIU WEI,DUTTA SANDEEP,POWELL John,MAGINN Mark,CASSON Duncan,BEST Andrea,HALL Jerry A.,LIU Wei,DUTTA Sandeep
申请号:
SI201030768
公开号:
SI2448970T1
申请日:
2010.05.04
申请国别(地区):
SI
年份:
2014
代理人:
摘要:
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.