POWELL, JOHN,MAGINN, MARK,CASSON, DUNCAN,BEST, ANDREA,HALL, JERRY A.,LIU, WEI,DUTTA, SANDEEP
申请号:
HRP20140915
公开号:
HRP20140915T1
申请日:
2014.09.24
申请国别(地区):
HR
年份:
2014
代理人:
摘要:
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.