КЭРИ Стивен П. Л. (US),КРТОЛИКА Ана (US),ЛЕ МОАН Наташа (US),УИНГЕР Джонатан А. (US),ЛЕОНГ Кевин Г. (US)
申请号：
RU2017134953
公开号：
RU2017134953A
申请日:
2016.03.17
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
The invention provides methods to modulate hypoxia-mediated tumor immunity by administration of an O2 carrier polypeptide (e.g., an H-NOX protein). The methods of the invention target both hypoxia inducible factor 1 alpha (HIF-1α) pathways and non-HIF-1α pathways of tumor immunity. Such methods are useful in the treatment of a wide variety of cancers and may be used alone or in combination with other anti-cancer therapies.
