Stephen P. L. CARY,Ana KRTOLICA,Natacha LE MOAN,Jonathan A. WINGER,Kevin G. LEONG
申请号：
US15558957
公开号：
US20180243364A1
申请日:
2016.03.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides methods to modulate hypoxia-mediated tumor immunity by administration of an O2 carrier polypeptide (e.g., an H-NOX protein). The methods of the invention target both hypoxia inducible factor 1 alpha (HIF-1α) pathways and non-HIF-1α pathways of tumor immunity. Such methods are useful in the treatment of a wide variety of cancers and may be used alone or in combination with other anti-cancer therapies.
