STABILIZED AMORPHOUS FORMS OF IMATINIB MESYLATE THE FORMULATION IS A SOLID DISPERSION

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专利权人:

NOVARTIS AG

发明人:

GONCALVES, ELISABETE,KALB, OSKAR,MUTZ, MICHAEL,WIRTH, WOLFGANG,LAKSHMAN, JAY PARTHIBAN

申请号：

NZ58117608

公开号：

NZ581176A

申请日:

2008.06.05

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a pharmaceutical composition comprising a formulation principle that stabilizes the amorphous form of Imatinib mesylate and amorphous Imatinib mesylate (4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)-pyrimidin-2-ylamino-)phenyl]-benzamide), optionally together with at least one pharmaceutically acceptable carrier, wherein the formulation principle is a solid dispersion. The form is preferably a gelatine capsule or a tablet.

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