FIELD: medicine； pharmaceuticals.SUBSTANCE: invention relates to compounds of formula IA, having properties of BCL-2 inhibitors, pharmaceutical compositions based thereon, use, a method of treating and a kit for treating diseases, disorders or conditions susceptible to BCL-2 protein inhibition, including hyperproliferative protein, such as cancer. In general formula IA: A is selected from a group consisting of:E is a carbon atom and is a double bond； or E is -C(H)- and is a single bond； or E is a nitrogen atom and is a single bond； X1, X2, and X3 are each independently selected from a group consisting of -CR8 =； R1a and R1b, taken together with the carbon atom to which they are bonded, form 4-member cycloalkyl； or R1a and R1b, taken together with the carbon atom to which they are bonded, form 4-member heterocycle with 1 oxygen atom； R2 is selected from a group consisting of -NO2； R2a is selected from a group consisting of hydrogen and halogen； R3 is selected from a group consisting of hydrogen and -N(R4a)(R4b)； R4a is selected from a group consisting of C1-6 alkyl and 6-member (heterocycloalkyl) C1-6 alkyl with 1 to 2 oxygen atoms； R4b is selected from a group consisting of hydrogen and C1-4 alkyl； R5 is selected from a group consisting of 6-member (heterocycloalkyl) C1-6 alkyl with 1 oxygen atom； R6a , R6c, R6e, R6f, and R6g are each independently selected from a group consisting of hydrogen, C1-6 alkyl, 6-member heterocycloalkyl with 1 oxygen atom, C1-6 heteroalkyl with 1–2 oxygen atoms, and 6-member (heterocycloalkyl) C1-6 alkyl with 1 oxygen atom； R6b and R6d are each independently selected from a group consisting of hydrogen； and R8 is selected from a group consisting of hydrogen and halogen.I-A.EFFECT: treating diseases, disorders or conditions susceptible to BCL-2 protein inhibition, including hyperproliferative protein, such as cancer.49 cl, 7 tbl, 20 ex, 4 dwgИзобретение относится к соединениям Формулы I-A, обладающим свойствами ингибиторов BCL-2, фармац
