CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT PASTEUR
发明人:
Pierre CHARNEAU,Philippe DESPRES,Melissanne DE WISPELAERE,Philippe SOUQUE,Marie-Pascale FRENKIEL
申请号：
US16794854
公开号：
US20200230228A1
申请日:
2020.02.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a lentiviral vector-based Japanese encephalitis (JE) immunogenic composition. The present invention is directed to a recombinant lentiviral vector expressing the precursor of membrane (prM) and the envelope (E) protein, in particular glycoprotein of a Japanese encephalitis virus (JEV) or immunogenic fragments thereof. The present invention also provides cells expressing the lentiviral vector, uses and methods to prevent a JEV infection in a mammalian host, especially in a human or an animal host, in particular a pig or a piglet, preferably a domestic pig or a domestic piglet.
