STEPHAN HANESSIAN,LUCIANA AUZZAS,GIUSEPPE GIANNINI,CLAUDIO PISANO,LOREDANA VESCI,WALTER CABRI
申请号：
BRPI0809000
公开号：
BRPI0809000A2
申请日:
2008.03.12
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The present invention relates to a compound of Formula (I), its geometrical isomers, in an optically active form as enantiomers, diastereomers, as well as in the form of racemate, as well as pharmaceutically acceptable salts thereof, wherein R is selected from CONHOH, CONHCH2SH, CONHCH2SCOCH3, SH, SCOCH3, SCH3, N(OH)COH, COCONHCH3 and CF3 for the preparation of a medicament, in particular for selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells, for inducing differentiation of tumor cells in a tumor, for inhibiting the activity of histone deacetylase and for the treatment of primary cancer or secondary cancer.
