CHRISTIAN A.G.N. MONTALBETTI,JIANWEN FENG,PUI LENG LOKE,STEVEN STABEN
申请号：
BR112013023681
公开号：
BR112013023681A2
申请日:
2012.03.15
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.
