UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
FERRONE, SOLDANO,WANG, XINHUI
申请号：
CA2737758
公开号：
CA2737758C
申请日:
2009.09.18
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), alsoknown as high molecular weightmelanomal associated antigen, is overexpressed on basal breast carcinoma cells(BBC), specifically triple negative basal breastcarcinoma cells (TNBC). Methods for detecting basal breast cancer in a subjectare disclosed. Methods are also disclosed for inhibitingthe growth of a basal breast cancer cell. These methods include contacting thebasal breast cancer cancer cell with an effectiveamount of an antibody that specifically binds CSPG4. Additional treatmentmethods, and the use of antibody panels, arealso described herein.
