Robert C. Rose;Jacob J. Schlesinger;Olivia K.T. Block;Xia Jin;W.W. Shanaka I. Rodrigo
发明人:
Jacob J. Schlesinger,Xia Jin,Robert C. Rose,Olivia K.T. Block,W.W. Shanaka I. Rodrigo
申请号:
US13876893
公开号:
US20130295162A1
申请日:
2011.10.03
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The disclosure provides a tetravalent Dengue virus vaccine, and methods of inducing a immune response against a Flavivirus such as Dengue virus 1-4 using the vaccine. The disclosure also provides methods of making a vaccine by introducing into a host cell a transgene that encodes a protein comprising Dengue domain III polypeptides, or, by purified dill polypeptides specific for Dengue serotypes 1-4, Yellow Fever Virus, West Nile Virus, Japanese Encephalitis Virus, and Flaviviruses.