An inhaler for delivering a powdered medicament from a container. The inhaler includes a flow channel, an opening means and a housing. The flow channel includes a conduit extending from an inlet to an outlet and includes a medicament introduction region within which a powdered medicament can be introduced. The housing includes a loading member which includes a holder for receiving a medicament container. The loading member can be manually moved between a loading position, in which a container can be manually loaded into, or removed from, the holder, and an inhalation position in which the powdered medicament can be introduced into the flow channel. The movement of the loading member from the loading position to the inhalation position causes the opening means to break a seal on the container, thereby exposing the powdered medicament for introduction into the flow channel.