NOVEL INDENE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RETINAL DISEASES CONTAINING SAME AS ACTIVE INGREDIENT
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
发明人:
KIM, EUN HEEKR,김은희,YOO, SUNG EUNKR,유성은,KANG, NAM SOOKKR,강남숙,KOO, TAE SUNGKR,구태성,PARK, MIN YOUNGKR,박민영,KIM, YOUNG HOONKR,김영훈,BAE, HYUN JUKR,배현주,KIM, JIN WOOKR,김진우,IN, TAE KYUKR,인태규,JOO, CHOUN KIKR,주천기,KIM, EUN HEE,YOO, SUNG EUN,KANG, NAM SOOK,KOO, TAE SUNG,PARK, MIN YOUNG,KIM, YOUNG HOON,BAE, HYUN JU,KIM, JIN WOO,IN, TAE KYU,JOO, CHOUN KI
申请号：
KR1020140095676
公开号：
KR1015513130000B1
申请日:
2014.07.28
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a novel indene derivative, a preparation method thereof, and a pharmaceutical composition for treating or preventing retinal diseases containing the same as an active ingredient. The novel indene derivative, optical isomers thereof, or pharmaceutically acceptable salt thereof has excellent effect of suppressing receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Accordingly, the composition containing the same as an active ingredient can be used for treating or preventing retinal diseases such as retinitis pigmentosa (RP), leber congenital amaurosis (LCA), stargardts disease, usher syndrome, choroideremia, rod-con or con-rod dystrophy, ciliopathy, mitochondrial dysfunction, progressive retinal atrophy, degenerative retinal disease, age-related macular degeneration (AMD), wet AMD, dry AMD, maplike atrophy, familial or acquired maculopathy, retinal photoreceptor diseases, retinal pigment epithelial-based diseases, diabetic retinopathy, cystoids macular edema, uveitis, retinal detachment, traumatic retinal damage, iatrogenic retinal damage, macular hole, retinal capillary ectasia, ganglion cell disease, optic nerve cell disorders, glaucoma, optic neuropathy, ischemic retinopathy, retinopathy of prematurity, retinal vein occlusion, familial macroaneurysm, retinal vascular disorders, eye vascular diseases, retinal nerve cell degeneration due to glaucoma, or ischemic optic neuropathy.COPYRIGHT KIPO 2015본 발명은 신규한 인덴 유도체, 이의 제조방법, 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 인덴 유도체, 이의 광학 이성질체, 또는 이의 약학적으로 허용가능한 염은 RIPK1(Receptor-interacting serine/threonine-protein kinase 1)의 억제 효과가 뛰어나므로, 이를 유효성분으로 함유하는 조성물은 색소성 망막염 (RP), 레베르 선천 흑암시 (LCA), 스타가르트병, 어셔 증후군, 맥락막 결여, 로드-콘 또는 콘-로드 디스트로피, 섬모병증, 미토콘드리아 장애, 진행성 망막 위축증, 퇴행성 망막 질환, 노화-관련된 황반 변성 (AMD), 습성 AMD, 건성 AMD, 지도상 위축증, 가족형 또는 획득 황반병증, 망막 광수용체 질환, 망막 색소 상피-계 질환, 당뇨병성 망막증, 낭포성 황반 부종, 포도막염, 망막박리, 외상성 망막 손상, 의원성 망막 손상, 황반 원공, 황반 모세관확장증, 신경절 세포 질환, 시신경 세포 질환, 녹내장, 시신
