593797 Disclosed are substituted dihydropyrazolone derivatives of formula (I), wherein the substituents are as described within the specification. An examples of compounds of formula (I) is 2-[5-(piperidin-1-ylsulfonyl)pyridine-2-yl]-1,2,4,5,6,7-hexahydro-3H-indazol-3-one. Further disclosed is a process for preparing a compound of formula (I), a pharmaceutical composition comprising formula (I), and the use of a compound of formula (I) in the manufacture of a medicament for the treatment/prophylaxis of cardiovascular diseases, glaucoma, neurodegenerative diseases, etc.