Federalnoe gosudarstvennoe avtonomnoe obrazovatelnoe uchrezhdenie vysshego obrazovaniya "Severnyj (Arkticheskij) federalnyj universitet imeni M.V. Lomonosova"
发明人:
Bogolitsyn Konstantin Grigorevich (RU),Боголицын Константин Григорьевич (RU),Kaplitsin Platon Aleksandrovich (RU),Каплицин Платон Александрович (RU),Druzhinina Anna Sergeevna (RU),Дружинина Анна Серге
申请号：
RU2018109052
公开号：
RU0002676271C1
申请日:
2018.03.14
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: pharmaceuticals.SUBSTANCE: invention relates to pharmaceutical industry, in particular to a method for complex processing of fucus algae. Method of complex processing of fucus algae with simultaneous production of a full range of biologically active substances from algae biomass in a single technological cycle, which consists in processing ground air-dry raw materials by supercritical fluid extraction, solvent – supercritical CO2, co-solvent ethanol, the obtained supercritical extract is divided into fractions with the prevailing content of components – polyphenols and fatty acids, after the supercritical fluid extraction algal residue is subjected to extraction with water with constant stirring, the extract is evaporated on a rotary evaporator and separated by addition of ethyl alcohol, the precipitated laminaran and fucoidan are separated from the solution by centrifuging, supernatant is cooled and left to precipitate mannitol from the solution for a day, then ethanol is removed from the aqueous-alcoholic extract using a rotary evaporator, evaporating the aqueous-alcoholic extract to the original volume, the resulting aqueous solution is diluted, acidified with concentrated hydrochloric acid and three-fold liquid-phase extraction of the polyphenol fraction from an aqueous solution of brown algae with a mixture of ethyl acetate and n-butanol is carried out, then after aqueous extraction the algal residue is treated with a solution of NaHCO3 with hydronic module, extracts are combined, acidified with concentrated sulfuric acid, the precipitated sodium alginate is used to produce various alginic acid salts, after the separation of alginates fibrous residue – algal fiber is purified by fourfold extraction with water at the boiling point of the solvent with a water duty, under certain conditions.EFFECT: described method allows to obtain not only a carbohydrate fraction (mannitol, alginic acids, fucoidan), but also a lipid-pigment complex, the polyphenolic comple
