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Dna aptamer capable of binding to non-small cell lung cancer cell (h1975)
专利权人:
发明人:
FURUSHO, HITOSHI,古性均,古性均
申请号:
TW105104143
公开号:
TW201643249A
申请日:
2016.02.05
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
The present invention addresses the problem of providing a novel DNA aptamer useful for the diagnosis and treatment of lung cancer, the prevention of metastasis of lung cancer and the like. A DNA aptamer which is characterized by having at least one nucleotide sequence selected from sequences respectively represented by SEQ ID NOs: 1 and 2, and is also characterized by being capable of binding specifically to a non-small cell lung cancer cell a composition for detecting a lung cancer cell, which contains the DNA aptamer a kit for detecting a lung cancer cell, which contains the DNA aptamer a method for detecting lung cancer, which is characterized by using the DNA aptamer a detection method comprising a step of bringing the DNA aptamer into contact with a sample collected from a living body, selected from the group consisting of a lung cell, a lung tissue, blood, serum, plasma, saliva and sputum and a step of observing a response associated with the binding of the sample to the DNA aptamer to detect the presence of a lung cancer cell a pharmaceutical composition for preventing the metastasis of lung cancer or treating lung cancer, which contains the DNA aptamer and a drug delivery system for preventing the metastasis of lung cancer or treating lung cancer, which contains the DNA aptamer.本發明的課題為提供有用於肺癌之診斷、治療、及轉移預防等的新穎DNA適體。一種DNA適體,其特徵為具有由序列編號1及2表示之序列中選擇的至少1個核苷酸序列,且對非小細胞肺癌細胞特異性地結合;一種檢測用組成物,其係包含該DNA適體之肺癌細胞;一種肺癌細胞之檢測用套組,其係包含該DNA適體;一種肺癌之檢測方法,其特徵為使用該DNA適體;一種檢測方法,其係包含使該DNA適體與由選自由肺細胞、肺組織、血液、血清、血漿、唾液、及喀痰所成之群的生體所採取之試樣接觸的步驟、及藉由觀測該試樣與DNA適體之結合所致的反應來檢測肺癌細胞之存在的步驟;一種肺癌之轉移預防或治療用醫藥組成物,其係含有該DNA適體;一種肺癌之轉移預防或治療用藥物傳輸系統,其係含有該DNA適體。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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