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HETEROARYLENE BRIDGED BENZODIAZEPINE DIMERS CONJUGATES THEREOF AND METHODS OF MAKING AND USING
专利权人:
发明人:
MCDONALD IVAR M,CHOWDARI NAIDU S,JOHNSON WALTER LEWIS,ZHANG YONG,BORZILLERI ROBERT M,GANGWAR SANJEEV
申请号:
IN201717028490
公开号:
IN201717028490A
申请日:
2017.08.10
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
Benzodiazepine dimers having a structure represented by (I) wherein X comprises a heteroaromatic moiety and is as further defined in the application; Ris (Ia) or (Ib); and the other variables in formulae (I) (Ia) and (Ib) are as defined in the application. Such dimers are useful as anti cancer agents especially when used in an antibody drug conjugate (ADC).
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