MCDONALD, IVAR M.,CHOWDARI, NAIDU S.,JOHNSON, WALTER LEWIS,ZHANG, YONG,BORZILLERI, ROBERT M.,GANGWAR, SANJEEV
申请号：
CA2973355
公开号：
CA2973355A1
申请日:
2016.01.13
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Benzodiazepine dimers having a structure represented by (I) wherein X comprises a heteroaromatic moiety and is as further defined in the application； R1 is (Ia) or (Ib)； and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
