UNIVERSITY OF WASHINGTON;ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (ERASMUS MC)
发明人:
KOELLE, David M.,JING, Lichen,JOHNSTON, Christine,WALD, Anna,VERJANS, George M.G.M.
申请号：
WO2016US43645
公开号：
WO2017019533(A1)
申请日:
2016.07.22
申请国别(地区):
世界知识产权组织国际局
年份:
2017
代理人:
摘要：
The invention provides multiple epitopes of HSV UL39 that are cross-reactive and are useful for the prevention and treatment of alphaherpesvirus infection across a broad spectrum of the population. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing epitopes or polynucleotides encoding epitopes of the invention provide effectively targeted vaccines for prevention and treatment of alphaherpesvirus infection.
