ASTRAZENECA UK LIMITED;BRISTOL-MYERS SQUIBB COMPANY
发明人:
NARANG, AJIT,RAO, VENKATRAMANA M.,DESAI, DIVYAKANT S.
申请号：
CA2826391
公开号：
CA2826391C
申请日:
2012.01.31
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to solid, semisolid, or liquid formulations comprising amine compounds that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf -life storage. The formulations of the present invention prevent or reduce formation of N- formyl impurities (and gelatin crosslinking) during the manufacturing process and/or during shelf -life storage.
