AstraZeneca UK Limited;Bristol-Myers Squibb Company
发明人:
申请号：
EP12704975.7
公开号：
EP2670397A1
申请日:
2012.01.31
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention relates to solid, semisolid, or liquid formulations comprising water soluble antioxidants that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf-life storage. The formulations of the present invention prevent or reduce formation of N-formyl impurities (and gelatin crosslinking) during the manufacturing process and/or during shelf-life storage.
