BROWN, DAVID RYALL,COLLINS, IAN,CZAPLEWSKI, LLOYD GEORGE,HAYDEN, DAVID JOHN
申请号：
PL07712942
公开号：
PL1996180T3
申请日:
2007.03.22
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
Compounds of formula (I) have antibacterial activity: wherein R represents hydrogen or 1, 2 or 3 optional substituents； W is &boxH；C(R1)&mdash； or &boxH；N&mdash；； R1 is hydrogen or an optional substituent and R2 is hydrogen, methyl, or fluorine； or R1 and R2 taken together are &mdash；CH2&mdash；, &mdash；CH2CH2&mdash；, &mdash；O&mdash；, or, in either orientation, &mdash；O&mdash；CH2&mdash； or &mdash；OCH2CH2&mdash；； R3 is a radical of formula -(Alk1)m-(Z)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z is &mdash；O&mdash；, &mdash；S&mdash；, &mdash；S(O)&mdash；, &mdash；S(O2)&mdash；, &mdash；NH&mdash；, &mdash；N(CH3)&mdash；, &mdash；N(CH2CH3)&mdash；, &mdash；C(&boxH；O)&mdash；, &mdash；O&mdash；(C&boxH；O)&mdash；, &mdash；C(&boxH；O)&mdash；O&mdash；, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms； or an optionally substituted divalent bicyclic heterocyclic radical having 5 to 10 ring atoms； Alk1 and Alk2 are optionally substituted C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by &mdash；O&mdash；, &mdash；S&mdash；, &mdash；S(O)&mdash；, &mdash；S(O2)&mdash；, &mdash；NH&mdash；, &mdash；N(CH3)&mdash；, or &mdash；N(CH2CH3)&mdash；； and Q is hydrogen, halogen, nitrile, or hydroxyl or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms； or an optionally substituted bicyclic heterocyclic radical having 5 to 10 ring atoms.
