Coppola, Gary Mark,Iwaki, Yuki,Karki, Rajeshri Ganesh,Kawanami, Toshio,Ksander, Gary Michael,Mogi, Muneto,Sun, Robert
申请号：
ES13151795
公开号：
ES2602902T3
申请日:
2010.05.26
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I ': ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is H, C1-7alkyl, hydroxy, C1-7alkoxy, halogen, -SH, -S-C1-7alkyl or NRaRb ； R2 for each occurrence is independently C1-7alkyl, halo, NO2, CN, C1-7alkanoylamino, C3-7cycloalkyl, hydroxy, C1-7alkoxy, haloC1-7alkyl, -NRaRb, C6-10aryl, heteroaryl or heterocyclyl； wherein Ra and Rb for each occurrence are independently H or C1-7alkyl； R3 is A1-C (O) X1； R5 10 is H, halo, hydroxy, C1-7alkoxy, halo, C1-7alkyl or halo-C1-7alkyl； and X and X1 are independently OH, -O-C1-7alkyl, -NRaRb, -NHS (O) 2-C1-7alkyl, -NHS (O) 2-benzyl or -O-C6-10aryl； wherein alkyl is optionally substituted with one or more substituents independently selected from the group consisting of C6-10aryl, heteroaryl, heterocyclyl, C (O) NH2, C (O) NH-C1-6alkyl, and C (O) N (C1 -6alkyl) 2； B1 is -C (O) NH- or-NHC (O) -； A1 is a linear or branched C1-7alkylene； which is optionally substituted with one or more substituents independently selected from the group consisting of halo, C3-7cycloalkyl, C1-7alkoxy, hydroxy, O-Acetate； wherein two germ alkyl can optionally be combined to form a C3-7cycloalkyl； or A1 is a linear or branched C1-7alkenylene； or A1 is a linear C1-4alkylene where one or more carbon atoms are replaced by a heteroatom selected from O, NRc； and A1 is optionally substituted with one or more substituents independently selected from the group consisting of halo and C1-7alkyl； wherein Rc for each occurrence, is independently H, C1-7alkyl, -C (O) -O-C1-7alkyl, or -CH2C (O) OH； and n is 0, 1, 2, 3, 4 or 5； wherein each heteroaryl is a monocyclic or bicyclic aromatic ring comprising from 5-10 ring atoms selected from carbon atoms and 1 to 5 heteroatoms, and each heterocyclyl is a monocyclic saturated or partially saturated, but not aromatic, structural unit comprising 4 -7 ring atoms selected from carbon atoms and 1-5 heteroatoms, wherein each heteroatom of a heteroaryl or a heterocyclyl is independentl
