RENASCIENCE CO., LTD.;TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
发明人:
ITOKAWA, MASANARI,MIYATA, TOSHIO,ARAI, MAKOTO
申请号：
HRP20140993
公开号：
HRP20140993T1
申请日:
2014.10.16
申请国别(地区):
HR
年份:
2014
代理人:
摘要：
The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene； (2) the expression level or activity of glyoxalase I in a biological sample； (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound； and (4) the amount of pyridoxal in a biological sample.
