您的位置: 首页 > 农业专利 > 详情页

CONJUGUÉS D'ADMINISTRATION DE POLYNUCLÉOTIDE IN VIVO AYANT DES LIAISONS SENSIBLES À DES ENZYMES
专利权人:
ARROWHEAD RESEARCH CORPORATION
发明人:
ROZEMA, DAVID, B.,LEWIS, DAVID, L.,WAKEFIELD, DARREN, H.,KITAS, ERIC, A.,HADWIGER, PHILIPP,WOLFF, JON, A.,ROEHL, INGO,MOHR, PETER,HOFFMANN, TORSTEN,JAHN-HOFMANN, KERSTIN,MUELLER, HANS, MARTIN,OTT, GUE
申请号:
EP11853858
公开号:
EP2658579A4
申请日:
2011.12.28
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active poiyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalentiy linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充