ROZEMA, DAVID B.,LEWIS, DAVID L.,WAKEFIELD, DARREN H.,KITAS, ERIC A.,HADWIGER, PHILIPP,WOLFF, JON A.,ROEHL, INGO,MOHR, PETER,HOFFMANN, TORSTEN,JAHN-HOFMANN, KERSTIN,MUELLER, HANS MARTIN,OTT, GUENTHER
申请号：
CA2816042
公开号：
CA2816042A1
申请日:
2011.12.16
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention is directed compositions for targeteddelivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo.Targeted RNAi polynucleotides are administered together with co-targetedme!ittm dehvery peptides. Dehvery peptides provide membrane penetrationfaction for movement of the RNAi polynucleotides from outside the cell toinside the cell. Reversible modification provides physiologicalresponsiveness to the delivery peptides.
