CHARIFSON, PAUL S.,CLARK, MICHAEL P.,BANDARAGE, UPUL K.,BETHIEL, RANDY S.,BOYD, MICHAEL J.,DAVIES, IONA,DENG, HONGBO,DUFFY, JOHN P.,FARMER, LUC J.,GAO, HUAI,GU, WENXIN,KENNEDY, JOSEPH M.,LEDFORD, BRIA
申请号：
PE0001562014
公开号：
PE12092014A1
申请日:
2012.08.01
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to compounds that inhibit the replication of influenza viruses of formula (i) wherein X1 is - F, - CL, - CF3, among others x2 is H, F, CL, CH is Z1, Z2, Z3 is CR0 is n, CH, N and - (C r4r5) - (r6r7) [c] n - Q - C (R4) = C (r6) - Q R0 is - H, - F, - CN R1, R2 and R3 are each independently - CH3, CH2f, - CF3,Among others, R4 and R5 are each independently - H, R6 and R7 are each independently - H, - Oh, - CH3, among others Q is - - Oh, CH2OH, among others n is 0 - 1.Preferred compounds are (R) - 3 - (2 - (5 - Chloro - 1H pyrrolo [2,3-b] pyridin-3-yl) - 5 - fluoropirimidin - 4 - 4.4 - dimetilpentanoico ilamino) - (R) - 3 - ((2 - (5 - fluoro - 5 - fluoro - 1H pyrrolo [2,3-b] pyridin-3-yl) pyrimidin-4-yl) amino) - 4.4 - dimetilpentanoico, among others. It also relates to a Pharmaceutical composition that is useful in the treatment of influenza.SE REFIERE A COMPUESTOS INHIBIDORES DE LA REPLICACION DE VIRUS DE INFLUENZA DE FORMULA (I) DONDE X1 ES -F, -CL, -CF3, ENTRE OTROS X2 ES -H, -F, -CL Z1 ES N, CH, Z2 ES N, CR0 Z3 ES CH, N Y ES -C(R4R5)-[C(R6R7)]N-Q , -C(R4)=C(R6)-Q R0 ES -H, -F, -CN R1, R2, R3 SON CADA UNO E INDEPENDIENTEMENTE -CH3, -CH2F, -CF3, ENTRE OTROS R4 Y R5 SON CADA UNO INDEPENDIENTEMENTE -H R6 Y R7 SON CADA UNO INDEPENDIENTEMENTE -H, -OH, -CH3, ENTRE OTROS Q ES -OH, -CH2OH, ENTRE OTROS n ES 0-1 . SON COMPUESTOS PREFERIDOS (R) -3-(2-(5-CLORO-1H-PIRROLO[2,3-B]PIRIDIN-3-IL)-5-FLUOROPIRIMIDIN-4-ILAMINO)-4,4-DIMETILPENTANOICO, (R) -3-((5-FLUORO-2-(5-FLUORO-1H-PIRROLO[2,3-B]PIRIDIN-3-IL)PIRIMIDIN-4-IL)AMINO)-4,4-DIMETILPENTANOICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE INFLUENZA.
