CHARIFSON PAUL S.,CLARK MICHAEL P.,BANDARAGE UPUL K.,BETHIEL RANDY S.,BOYD MICHAEL J.,DAVIES IOANA,DENG HONGBO,GAO HUAI,GU WENXIN,FARMER LUC J.,DUFFY JOHN P.,KENNEDY JOSEPH M.,REDFORD BRIAN,LEDEBOER M
申请号：
ARP120102809
公开号：
AR087418A1
申请日:
2012.08.01
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Process and middleman claim 1: structural compound (1),CH3, CH3, CH3, CH3, CH3, CH3, CH3, CH3, CH3, CH3, CH3, CH3, CH3, CH3, CH3, 2cf3； or, as an alternative, R2 and R3 or R1, R2 and R3 form a 3-10 carbon cycle together with the carbon atoms they are connected to； R4 and R5 are h； R6 and R7 are h, oh, CH3 or CF3 respectively； or R5 and R7 can be selected, plus the carbon atoms they are connected to,Each q is independent. C (o) o r, oh, CH2OH, s (o) R rsqoe；,-P (O) (OH) 2 -S (O) 2R 26rsquo-S (o) 2-nr rsqoe； rsqoe； R rsqoe； rsqoe； rsqoe； or 5 members from the formula group (2)；JQ es-h-oh o-ch2oh； res-h or C1-4； R rsqoe； es-oh, C1-4 o-ch2c (o) Oh； R rsque； rsqoe； es-h, R rsqoe； rsqoe； es-h, a 3-6 carbon cycle or C1-4 tar, optionally replaced, with one or more alternatives selected from the halogen group； o-ora-c； or C1-4, n is 0 or 1. Claim 50: a compound represented by a structural formula (3) or a salt acceptable to a drug, wherein the structural formula variables (3) are independent variables as defined in any one of claims 1-38； if Z1 is n, G is tributyl；When Z1 is ch, G is cough or tributyl.Proceso de elaboración e intermediario.Reivindicación 1: Un compuesto representado por la fórmula estructural (1), o una de sus sales farmacéuticamente aceptables, en donde: X1 es -F, -Cl, -CF3, -CN o CH3； X2 es -H, -F o -Cl； Z1 es N o CH； Z2 es N o CR0； Z3 es CH o N； Y es -C(R4R5)-[C(R6R7)]n-Q o -C(R4)=C(R6)-Q； R0 es -H, -F o CN； R1, R2 y R3 son, cada uno y de modo independiente, -CH3, -CH2F, -CF3, -C2H5, -CH2CH2F, -CH2CF3； o, de modo opcional, R2 y R3 o R1, R2 y R3, junto con el átomo de carbono al que están unidos, forman un anillo carbocíclico de 3 - 10 miembros； R4 y R5 son, cada uno y de modo independiente, -H； R6 y R7 son, cada uno y de modo independiente, -H, -OH, -CH3 o -CF3； o de modo opcional, R5 y R7, junto con los átomos de carbono a los que están unidos, forman un anillo ciclopropano； y cada Q es, de modo independiente, -C(O)OR, -OH, -CH2OH, -S(O)R&rs
