A method of administering a composition having Cannabis sativa-derivedsubstancesnano-encapsulated in phospholipid vesicles for transmucosal and transdermaldelivery isdisclosed. A Cannabis sativa-derived formulation for transmucosal andtransdermal deliverycomprising Cannabis sativa-derived compounds nanoencapsulated in phospholipid-based vesiclesis also disclosed. Cannabis sativa-derived extracts have enhancedbioavailability whenencapsulated in nanosized phospholipid vesicles prior to administration to asubject as comparedto non-encapsulated cannabinoids. A method of encapsulating cannabis-derivedcompounds innanosized phospholipid vesicles is also disclosed
