A method of encapsulating cannabis-derived compounds in nanosized phospholipidvesicles is disclosed. A Cannabis sativa-derived formulation for transmucosaland transdermaldelivery comprising Cannabis sativa-derived compounds nanoencapsulated inphospholipid-basedvesicles is also disclosed. Cannabis sativa-derived extracts have enhancedbioavailability whenencapsulated in nanosized phospholipid vesicles prior to administration to asubject as comparedto non-encapsulated cannabinoids. Also disclosed herein are methods oftransmucosal andtransdermal administration of the formulation having phospholipid vesicleswith nanoencapsulatedCannabis sativa-derived substances.
