A method of administering a composition having Cannabis sativa-derived substances nano-encapsulated in phospholipid vesicles for transmucosal and transdermal delivery is disclosed. A Cannabis sativa-derived formulation for transmucosal and transdermal delivery comprising Cannabis sativa-derived compounds nanoencapsulated in phospholipid-based vesicles is also disclosed. Cannabis sativa-derived extracts have enhanced bioavailability when encapsulated in nanosized phospholipid vesicles prior to administration to a subject as compared to non-encapsulated cannabinoids. A method of encapsulating cannabis-derived compounds in nanosized phospholipid vesicles is also disclosed
