BRIDGED BICYCLIC INHIBITORS OF MENIN-MLL AND METHODS OF USE

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专利权人:

INC.;THE REGENTS OF THE UNIVERSITY OF MICHIGAN;KURA ONCOLOGY, INC.;KURA ONCOLOGY

发明人:

WU, Tao,LI, Liansheng,WANG, Yi,REN, Pingda,GREMBECKA, Jolanta,CIERPICKI, Tomasz,KLOSSOWSKI, Szymon,POLLOCK, Jonathan,BORKIN, Dmitry

申请号：

SG11201807834W

公开号：

SG11201807834WA

申请日:

2017.03.15

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

The present disclosure provides methods of inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The methods are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin. Compositions for use in these methods are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/