METHODS FOR INTEGRATING DNA INTO GENES WITH GAIN-OF-FUNCTION OR LOSS-OF-FUNCTION MUTATIONS

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专利权人:

发明人:

申请号：

EP21781917.6

公开号：

EP4126072A1

申请日:

2021.03.29

申请国别(地区):

EP

年份:

2023

代理人:

摘要：

Methods and compositions for modifying the 3' untranslated region or coding sequence of endogenous genes using rare-cutting endonucleases and donor molecules. The methods and compositions described herein can be used to modify the coding sequence of endogenous genes or to facilitate early termination of transcripts.

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