PROBLEM TO BE SOLVED: To provide food and drink and a medicine, having a function of fortifying originating tissue or preventing and ameliorating damages, through specifying the tissue or the form of the originating collagen.SOLUTION: This invention relates to: food and drink such as health food, and a medicine such as an anticancer agent, comprising type-IV collagen (biocomponent containing the same) and/or its fragment or peptide； an anticancer agent comprising an antibody for recognizing type-IV collagen and/or its fragment or peptide； a therapeutic agent for preventing and ameliorating osteoporosis comprising a collagen mixture containing type I collagen as a main component, or food and drink such as health food； and a therapeutic agent for preventing and ameliorating osteoporosis comprising collagen derived from bone (biocomponent containing the same) and/or type I collagen and or type III collagen (biocomponent containing them), or food and drink such as health food.【課題】コラーゲンの由来組織や型を特定して用いることで、所属組織の強化、障害予防の、改善機能を有する飲食物・医薬品の提供。【解決手段】タイプＩＶコラーゲン（これを含む生体成分）及び又はその分画やペプタイドより成る健康食品等の飲食物・抗癌剤等の医薬品。タイプＩＶコラーゲンを及び又はその分画やペプタイドを認識する抗体よりなる抗癌剤。タイプＩコラーゲンを主成分とするコラーゲン混合物より成る骨粗鬆症予防及び改善治療剤又は健康食品等の飲食物。骨由来コラーゲン（これを含む生体成分）及び又はタイプＩコラーゲン及び又はタイプＩＩＩコラーゲン（これらを含む生体成分）より成る骨粗鬆症予防及び改善治療剤又は健康食品等の飲食物。【選択図】なし
