COMPOSES PYRAZOLE ET PYRROLE SUBSTITUES ET PROCEDES D'UTILISATION DE CES DERNIERS POUR L'INHIBITION DE L'INITIATION DE LA TRADUCTION ET LE TRAITEMENT DE MALADIES ET DE TROUBLES ASSOCIES A CETTE DERNIERE
SIDDIQUI, M. ARSHAD,CIBLAT, STEPHANE,DERY, MARTIN,CONSTANTINEAU-FORGET, LEA,GRAND-MAITRE, CHANTAL,GUO, XIANGYU,SRIVASTAVA, SANJAY,SHIPPS, GERALD W.,COOPER, ALAN B.,BRUNEAU-LATOUR, NICOLAS,LY, VU LINH
申请号：
CA3025492
公开号：
CA3025492A1
申请日:
2016.06.01
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure (I) and pharmaceutically acceptable salts and /V-oxides thereof, wherein X1, X2, Z1, Z2, the ring system denoted by "a", R1, A1A, L1B, A1B, L1A, L2, Q, L3, R3, A4A, L4B, A4B, L4A, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein disrupt the elF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.
