William L. Olbricht;George K. Lewis, JR.;George K. Lewis; JR.
发明人:
George K. Lewis, JR.,William L. Olbricht
申请号：
US13582663
公开号：
US20130046230A1
申请日:
2011.03.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method for convection-enhanced delivery (CED) of compounds and an apparatus for use with the method are provided. The apparatus, an ultrasound transducer cannula assembly (TCA) apparatus, can be used for the delivery of a compound to a target in the body such as a cells, tissue or organ in a healthy or diseased state. The ultrasound TCA apparatus comprises a transducer cannula assembly (TCA) and an ultrasound system to enhance penetration of molecules in the target. The ultrasound system may be portable and pocket-sized. The inclusion of ultrasound in the apparatus improves the distribution volume of material four to six times over a convection-enhanced delivery system without ultrasound. Since the targeting can be more focused, less compound is needed, thus lowering the potential for harmful effects to the host and host cells.
