A portable ultrasound system includes a user interface system including at least one display screen and at least one user input device, a processing circuit configured to perform general computing operations and configured to receive ultrasound imaging data from a removable ultrasound module, a housing containing the user interface system and the processing circuit and having an opening configured to removably receive the removable ultrasound module, and a connector configured to form an electrical connection with a corresponding second connector of the removable ultrasound module when the removable ultrasound module is fully inserted into the portable ultrasound system through the opening of the housing, and wherein the connector includes at least one guiding feature configured to align the connector and the second connector as the removable ultrasound module is inserted into the portable ultrasound system.