H. Lee Moffitt Cancer Center and Research Institute Inc.
发明人:
DAVILA, Marco
申请号：
AU2019247371
公开号：
AU2019247371A1
申请日:
2019.04.04
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Disclosed are compositions and methods for targeted treatment of infections and cancers expressing cancers. In particular, chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer to target and kill transformed and infected cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an immunotherapy in a subject with an infection or cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
