H. Lee Moffitt Cancer Center and Research Institute; Inc.
发明人:
Marco L. Davila
申请号：
US16485296
公开号：
US20190374579A1
申请日:
2018.02.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are chimeric antigen receptor (CAR) polypeptides that can be used with adoptive cell transfer to target and kill TIM3-expressing cancers. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with a TIM3-expressing cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
