Inc.;H. Lee Moffitt Cancer Center and Research Institute
发明人:
Daniel Abate-Daga,Alan F. List,Sheng Wei
申请号：
US16467286
公开号：
US20190309086A1
申请日:
2017.12.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are chimeric antigen receptor (CAR) polypeptides that can be used with adoptive cell transfer to target and kill cancer cells that express TLR9 on their surface. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with a TLR9-expressing cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
