< Topic >Controlling the coloration of the donepejiru content sticking formulation, among other things actualizing the appearance of natural color tone.SolutionsIn the aforementioned adhesive layer, with asukorubin acid or it can soak with that metal salt or ester and meta the sulfurous acid metal salt heavily in the method the backing and adhesive layer of possessing, including with adhesive and donepejiru to adhesive layer, controlling the coloration of the sticking formulation. In this method, granting process and aforementioned compound ones which prepare adhesive and donepejiru and asukorubin acid or that metal salt or compound ones which include ester and the meta heavily sulfurous acid metal salt to the aforementioned backing surface, the aforementioned adhesive layer the process which forms a membrane and, it is desirable to possess.< Selective figure >It is not【課題】ドネペジル含有貼付製剤の着色を抑制して自然な色合いの外観を実現すること等。【解決手段】支持体と粘着剤層とを有し、粘着剤層に粘着剤とドネペジルとを含む、貼付製剤の着色を抑制する方法において、前記粘着剤層に、アスコルビン酸またはその金属塩もしくはエステルとメタ重亜硫酸金属塩とを含ませる。かかる方法において、粘着剤とドネペジルとアスコルビン酸またはその金属塩もしくはエステルとメタ重亜硫酸金属塩とを含む調合物を準備する工程と、前記調合物を前記支持体表面に付与して前記粘着剤層を成膜する工程と、を有することが好ましい。【選択図】なし
