АЛЕКСАНДРОВА Красимира (DE),ПЕДИАДИТАКИС Питер (US),СОЛСБЕРИ Джо (US),РЮДИНГЕР Вольфганг (DE)
申请号：
RU2013143436/15
公开号：
RU2013143436A
申请日:
2013.09.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method for the prevention or therapeutic treatment of liver disease in a subject in need thereof, comprising administering microcapsules containing a capsule shell, encapsulating a suspension of a therapeutically effective amount of liver cells in physical contact with an amount of erythropoietin stimulating liver cells in need of this individual, where the administration is via intraperitoneal introduction. 2. The method of claim 1, wherein the liver cells are selected from the group consisting of liver cell progenitor cells, liver stem cells, hepatoblasts, endothelial cells, and hepatocytes. A method according to claim 1 or 2, wherein the liver cells are obtained from an adult liver or from liver cell cultures. The method of claim 1 or 2, wherein the liver cells are human liver cells, non-human primate liver cells, pig liver cells, dog liver cells, cat liver cells, rabbit liver cells, mouse liver cells, or rat liver cells. The method according to claim 1 or 2, where the average diameter of the microcapsules is from 100 to 700 microns. The method according to claim 1 or 2, where the average diameter of the liver cells is from 8 to 14 microns. A method according to claim 1 or 2, wherein the therapeutically effective number of liver cells is from 10 to 10 liver cells / ml suspension. A method according to claim 1 or 2, wherein the amount of erythropoietin stimulating the liver cells is from 10 to 10, preferably from 10 to 10 U / ml of the suspension. The method of claim 1 or 2, wherein the erythropoietin is wild-type erythropoietin or recombinant erythropoietin. The method according to claim 1 or 2, wherein the capsule shell is obtained from a biocompatible substance selected from the group consisting of1. Способ профилактики или терапевтического лечения заболевания печени у нуждающегося в этом индивидуума, включающий введение микрокапсул, содержащих оболочку капсулы, инкапсулирующую суспензию терапевтически эффективного количества клеток печени в физическом кон
