BONE HEATHER KARYN,TOSH DAVID,WELHAM MELANIE JOANNE
申请号：
IN4723/DELNP/2012
公开号：
IN2012DN04723A
申请日:
2012.05.28
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Described are methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a cell or population of cells characteristic of the definitive endoderm, the method comprising incubating the cell or population of cells with a GSK-3 inhibitor. Also described are methods for inducing differentiation of a cell or population of cells, characteristic of the definitive endoderm, towards a hepatocyte-like cell or a population of hepatocyte-like cells, and methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a hepatocytelike cell or a population of hepatocyte-like cells. Further described are cells obtained by the methods and uses thereof in therapy and toxicity screening.
