Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.本發明描述結合IL-1α及IL-1β之蛋白質,以及其在用於治療、預防及診斷IL-1相關病症以及用於偵測細胞、組織、樣本及組合物中之IL-1α及IL-1β之組合物及方法中的用途。