The present invention describes IL-1α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1α. Binding proteins of the invention have high affinity for IL-1α and neutralize IL-1α activity. A binding protein of the invention can be a full-length antibody or an IL-1α-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1α binding proteins of the invention are useful for detecting IL-1α and for inhibiting IL-1α activity, including in a human subject suffering from a disease or disorder in which IL-1α activity is detrimental.本發明提供IL-1α結合蛋白，包括結合IL-1α之嵌合、CDR移植及人類化抗體。本發明之結合蛋白對IL-1α具有高親和力且中和IL-1α活性。本發明之結合蛋白可為全長抗體或其IL-1α結合部分。本發明亦提供製造本發明之結合蛋白的方法及使用本發明之結合蛋白的方法。本發明之IL-1α結合蛋白適用於偵測IL-1α及抑制IL-1α活性，包括在罹患因IL-1α活性而受害之疾病或病症的人類個體中。
