GALLEY, GUIDO,GROEBKE ZBINDEN, KATRIN,NORCROSS, ROGER,STALDER, HENRI
申请号：
ES08701646
公开号：
ES2510546T3
申请日:
2008.01.23
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
The use of a compound of the formula ** formula ** in which R 1 is hydrogen, deuterium, tritium, C 1-7 alkyl, C 1-7 alkoxy, C 1-7 alkyl, substituted by halogen, C 1-7 alkoxy substituted by halogen , halogen, phenyl optionally substituted by halogen, or is phenyloxy, benzyl, benzyloxy, -COO-C 1-7 alkyl, -O- (CH 2) or O-C 1-7 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl or tetrahydropyran 4-yloxy, said substituents for n>； 1 may be the same or different； X is a link, -CHR-, -CHRCHR'-, -OCH2-, -CH2OCHR-, -CH2CH2CH2-, -SCH2-, -S (O) 2CH2-, -CH2SCH2-, - CH2N (R) CH2-, -C3-6-CH2- or SiRR'-CH2- cycloalkyl； R / R 'independently of one another may be hydrogen, C1-7 alkyl or C1-7 alkyl substituted by halogen； R2 is hydrogen, phenyl or C1-7 alkyl； Y is phenyl, naphthyl, thiophenyl, pyridinyl, C3-6 cycloalkyl, 1,2,3,4-tetrahydro-naphthalen-2-yl, 2,3-dihydrobenzo [1,4]-dioxin-6-yl or benzo [ 1,3] dioxol-5-yl； n is the number 0, 1, 2 or 3； or is the number 2 or 3； or to a pharmaceutically acceptable acid addition salt for the manufacture of medicaments for the treatment of diseases related to the biological function of receptors associated with trace amines, such diseases are neurological diseases, neurodegenerative disorders, Alzheimer's disease, epilepsy , migraine, dyslipidemia and disorders of energy consumption and assimilation.El uso de un compuesto de la fórmula **fórmula** en la que R1 es hidrógeno, deuterio, tritio, alquilo C1-7, alcoxi C1-7, alquilo C1-7, sustituido por halógeno, alcoxi C1-7 sustituido por halógeno, halógeno, fenilo opcionalmente sustituido por halógeno, o es feniloxi, bencilo, benciloxi, -COOalquilo C1-7, -O-(CH2)o-O-alquilo C1-7, NH-cicloalquilo C3-6, cicloalquilo C3-6 o tetrahidropiran-4-iloxi, dichos sustituyentes para n>；1 pueden ser iguales o diferentes； X es un enlace, -CHR-, -CHRCHR'-, -OCH2-, -CH2OCHR-, -CH2CH2CH2-, -SCH2-, -S(O)2CH2-, -CH2SCH2-, - CH2N(R)CH2-, -cicloalquilo C3-6-CH2- o SiRR'-CH2-； R/R' con independencia entre sí pueden ser hi
