Martinez Botella Gabriel,Harrison Boyd L.,Robichaud Albert Jean,Salituro Francesco G.,Beresis Richard Thomas
申请号：
US201816020641
公开号：
US2018311262(A1)
申请日:
2018.06.27
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I):;;and pharmaceutically acceptable salts thereof; wherein , R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
