Botella Gabriel Martinez;Harrison Boyd L.;Robichaud Albert Jean;Salituro Francesco G.;Beresis Richard Thomas;SAGE THERAPEUTICS, INC.
发明人:
Botella Gabriel Martinez,Harrison Boyd L.,Robichaud Albert Jean,Salituro Francesco G.,Beresis Richard Thomas
申请号：
US201515314565
公开号：
US2018179247(A1)
申请日:
2015.05.29
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.;
